Smart made his first field goal, a 3-pointer, with 17:46 to play. He drew the third foul on Embiid with 14:19 to go and the Jayhawks up 38-36. Wiggins picked up his third foul 11 seconds later.
Kansas responded with a run. With both freshman stars on the bench, Tharpe and Selden drained 3-pointers that helped put the Jayhawks up 46-38. A three-point play by Perry Ellis pushed Kansas' lead to nine, and a pair of free throws by Wiggins extended the margin to 10 for the first time.
Oklahoma State muscled its way back into the game with a three-point play by Nash and a long lob by Smart to Brown that cut Kansas' lead to five and got the crowd back into the game. The Cowboys moved into the double bonus with 5:50 remaining, and Brown made two free throws to give Oklahoma State a 60-59 lead.
The foul situation was a worst-case scenario for Kansas, given Smart's ability to attack.
"Of course, when you're the best guy in America at drawing fouls, you're going to be driving every time," Self said.
Smart's 3-pointer with 3:44 left put the Cowboys up 63-61. Oklahoma State then closed the game out, something the Cowboys struggled to do during their seven-game losing streak.
"That's what we're capable of doing every night," Brown said. "We were just poised out there on the court tonight, and we took advantage of the mistakes that Kansas made."
After the game, Self said that Embiid, who dealt with knee and back injuries a month ago, had "tweaked his back," according to CollegeBasketballTalk.com. He appeared to injure himself by landing awkwardly toward the end of the second half.
The Associated Press contributed to this report.