In the game, users pretend to be drug dealers in New York City trying to make as much money as possible in 30 days by trafficking illegal substances.
Macia said Apple rejected him because it violated the company's guidelines for developers.
In its Software Development Kit (SDK), it says that "Applications must not contain any obscene, pornographic, offensive or defamatory content or materials of any kind (text, graphics, images, photographs, etc.), or other content or materials that in Apple's reasonable judgment may be found objectionable by iPhone or iPod touch users."
But Macia told ABCnews.com that it's not like iTunes and the App Store don't contain any potentially offensive material. "The iTunes store has so many songs and movies about cocaine and killing people," he said.
And the number of farting applications easily exceeds 100, he added. "I find 137 farting applications objectionable," he said. "I find that a lot ruder than a game."
Macia went back to the drawing board, changed the name of the game to "Prohibition 1: Bootlegger," replaced the names of drugs with the names of alcohol and went back to Apple.
This time, the company approved it. Encouraged, Macia successfully submitted another game "Prohibition 3: Candy Wars," set in a future in which candy is illegal.
Since he'd scored with two games that were only cosmetically different from the original one that had been rejected, he tried once more. But, no such luck: It got the thumbs down again.
When an Iraqi journalist hurled his shoe at President George W. Bush during a news conference in December 2008, he inspired a monument, a host of Web games and, of course, an iPhone app.
But the glory of that game was short-lived.
The popular social media blog Mashable reported in February that "My Shoe," created by a developer in Pakistan, had been given the no-go by the App store team.
The game used the phone's accelerometer to let users pretend to throw a shoe at the former president.
In a rejection letter, Apple told the developer it determined that it could not "post this version of your iPhone application to the App Store because it contains content that ridicules public figures," according to Mashable.
But the developer reportedly took issue with Apple's rejection, writing, "I feel this is huge discrimination against public opinion, as a major portion of world rejects Bush polices on Iraq and attacks on Pakistan."
Patrick Alphonso, president of Swamiware, received a similar response from Apple when he submitted "Obama Trampoline."
The game, he thought, was pretty innocuous. You choose a U.S. politician from either side of the political aisle and have him or her jump on a trampoline in the Oval Office. Using the accelerometer, you could make Sarah Palin do a flip, tilt a pants-less Bill Clinton to the side or turn Barack Obama upside down.
Having already successfully submitted strategy, word and card games, he expected it to get the green light. But Apple gave a firm "no."
"I was shocked. I was expecting to make millions of dollars on this game," Alphonso told ABCNews.com. "It's fun. People were crazy about Obama, about Palin. The artwork was great."
"They said it ridiculed public officials," he said, adding that the rule seemed to be: no cartoons of politicians.