When Jackson returned, Murray rubbed his body with cream to treat the singer's vitiligo, a condition that discolors the skin. The singer took a valium and Murray put an IV near Jackson's knee and began administering doses of two sedatives, lorazepam and midazolam.
At 3 a.m., Jackson was still awake.
"I said: How about if you try to meditate?" Murray told police. "Let's change the lighting of the room, let's lower the music ... let me rub your feet and try to relax."
Jackson fell asleep for 10 or 15 minutes and awakened again. Murray said that nothing seemed to be working to get the singer to sleep, that he double-checked Jackson's IV because he couldn't understand how he was still awake after receiving several doses of the sedatives.
After 10 a.m., Jackson told Murray, "Please give me some milk so I can sleep because I know that's all that works for me."
Milk was Jackson's nickname for the white-colored propofol.
Finally, at 10:50 a.m., Murray said Jackson finally fell asleep after he administered the propofol.
"I made sure that there was oxygen on the bedside. ... I had a pulse oximeter ... that shows the amount of oxygen that he has in his blood and also allows me to look at the heart rate," Murray told investigators.
Murray said he gave Jackson just 25 milligrams of propofol.
Prosecutors say that Murray recklessly administered the drug and didn't properly monitor Jackson. They claim the oxygen tank was empty and that the pulse oximeter didn't have an audible alarm to alert someone if something was wrong.
Murray's phone records and the testimony of his girlfriends revealed that he exchanged texts and calls with at least four women on the morning Jackson died.
Murray told investigators that he went to the bathroom for a short time and returned to a lifeless Jackson.
Murray said he immediately began trying to ventilate Jackson through CPR and mouth-to-mouth resuscitation. He added that because Jackson didn't have a landline, it made it difficult to call for help.
"To speak to a 911 operator would be to neglect him," he said. "I want to ventilate him, do chest compressions enough to give him an opportunity."
He said that he felt a pulse in Jackson's groin area and administered CPR on Jackson's bed because he couldn't move him to the floor alone.
He said that while he administered CPR with one hand, he called Jackson's assistant on his cell phone for help but didn't advise him to call 911. Eventually, a bodyguard would run into the bedroom and call 911.
Murray showed little emotion as the tape played.
The police interview followed the playing of surveillance video of Murray leaving the UCLA Medical Center after Jackson was declared dead.
Det. Scott Smith of the Los Angeles Police Department told jurors that he went to the hospital on the day Jackson died, but was unable to track down Murray for an interview. He did talk briefly to Jackson's bodyguard and driver.
Smith added that the day after Jackson died, Jackson's family alerted him and the coroner of additional evidence found in the master bathroom of Jackson's mansion.
Pictures of the master bathroom showed a messy space with drawers open, notes taped to windows and things covering the floor.
The evidence included three empty pill bottles and a shaving bag full of rotten marijuana. Smith said police at first thought the marijuana was heroin.
ABC News' Jim Avila and Kaitlyn Folmer contributed to this report.