But after just five minutes with the Dutch playboy accused of murdering a 21-year-old Peruvian woman earlier this year, Twitty left without any new information, CNN reported, quoting Peru's "24 Horas" TV program. It was their first face-to-face meeting since Holloway's disappearance during a school vacation to Aruba.
Twitty's lawyer, John Q. Kelly, confirmed to ABC News hat Twitty had made the trip to the notorious Castro Castro prison on Wednesday with Dutch television reporter Peter R. de Vries. Kelly didn't learn of her plans until the day before, when Twitty had already been in Peru for two days.
"There wasn't much I could say," Kelly said. "She was there."
He declined to comment on exactly what the two talked about, but said she was planning to fill him in when she returned home, not wanting to share too many of the details over a cell phone
"I think the main thing was to let him know she's still around," Kelly said. "I think the message was that she is still looking for answers.
"But," he added, "she didn't expect to get them from him at this time."
This isn't the first time Twitty has tried to get answers from van der Sloot, paying him $25,000 in return for his promise to tell what happened to her daughter and where her body was buried. Van der Sloot then told Twitty's lawyer that it was encased in the foundation of a home, but it was later determined the house was not under construction at the time.
Earlier this month, van der Sloot told Dutch newspaper De Telegraaf that he extorted money from Natalee Holloway's parents for revenge.
"I wanted to get back at Natalee's family. Her parents have been making my life tough for five years," the newspaper quoted him as saying from prison in Peru. "When they offered to pay for the girl's location, I thought: 'Why not'?"
Holloway was last seen alive with him on Aruba in 2005. At various times he has confessed to killing the 18-year-old, though he later retracted the confessions.
In an interview in June with the same newspaper, van Der Sloot blamed himself for landing in a rat-filled Peruvian prison cell, but he suggested that the FBI lured him to Peru in a botched sting operation.
Van der Sloot's interview is the latest in a series of startling comments from the Dutch playboy charged with the murder of Stephany Flores, 21, of Peru, and the prime suspect in Holloway's disappearance.
Van der Sloot met Flores at a gambling table, and he has signed a confession admitting killing her while back at his hotel room in rage after she discovered his connection to the Holloway case and allegedly struck him.
He has since refuted his confession, saying he was tricked into signing it, believing he was just signing an acknowledgement of his legal rights. He is demanding that the confession be thrown out of court.
Nevertheless, he admitted to De Telegraaf that he should have listened to his mother.
"I am surviving," he told the paper. "It's my own fault I am here."
Van der Sloot said he understands why even his mother, Anita van der Sloot, told the paper that she can't visit him in prison and was quoted as saying, "Joran could have killed Stephany."
"I have caused her and many other people too much pain. If only I had listened to her," van der Sloot said.