The reality star made the announcement today.
"After a lot of careful thought and deliberation I have decided not to return to RHOBH as a full time cast member this season," Glanville said in a statement posted on Bravo's website. "The past four years have been amazing, a complete roller coaster of a ride. I will always be thankful to Bravo for the opportunities that have come along with doing this pop culture phenomenon of a show. In the meantime, I'm working hard on my podcast, my new wine business, and my clothing line. And keep an eye out for my next adventure that will show everyone a more well-rounded side of who I really am."
Glanville, 42, a former model, joined the show in its second season.
Earlier, she shared with listeners of her podcast "Brandi Glanville: Unfiltered" that she's open to returning to the show as a guest star.
"Bravo will always be my family. Like Andy [Cohen] said, 'It's the mafia, you never really get to leave us,'" she said. "They've been so great to me. And if I'm available and they need me, they know how to find me."
The author of the memoir "Drinking and Tweeting," Glanville was famously married to actor Eddie Cibrian when he had an affair with now-wife LeAnn Rimes. The three have publicly clashed in the past, often over Glanville's two sons with Cibrian.