Firts, he introduced himself, "I am Kanye West," which resulted in a roar of applause.
He then motioned to the crowd and said, "I see you Amber [Rose]," his own ex.
Kardashian West didn't seemed to mind and looked on adoringly at her husband.
"My wife is a G, not a lot of people's wives let them say that," he joked about Rose.
After talking about fame and calling Taylor Swift for his song "Famous," which she has denied he did, he turned the speech to politics.
"Last week it was 22 people murdered in Chicago," he said.
He also shared a short story about meeting a young kid who has lost friends to violence.
"Three of my friends died and I don't know if I'm going to be the next," the kid told West, so he added, "You might feel like what's the point ... life can start to feel worthless."
But then he said, "tonight we are here to have fun."
Before introducing his video for "Fade," he said, "we are undeniably the influence, the thought leaders."