"I want to thank you for your time and for coming to see our film," he said, according to People magazine. "This film has been a labor of love for us and we are desperately proud to present it to you."
Parker, along with his co-stars, including Gabrielle Union and Armie Hammer, will also be featured at a panel discussion Sunday at the Canadian film festival.
Praise for the film has been largely overshadowed recently by controversy over an old rape case involving Parker.
The actor -- who directed, starred, wrote and produced "Birth of a Nation" -- was accused of raping a fellow classmate while he was a student at Penn State University in 1999. Parker, 36, was later acquitted, but his college roommate and wrestling teammate, Jean Celestin, who also happens to be his collaborator on the film, was found guilty before his verdict was overturned. The accuser committed suicide in 2012 after many previous attempts.
"Birth of a Nation" swept all top categories at the Sundance Film Festival Awards in January, becoming only the fourth film to capture all of the festival's highest honors.
Fox Searchlight then won a record-setting bidding war to acquire the film's worldwide distribution rights. The studio will release the film in theaters Oct. 7.