The late-night shows found the topic rich for attack on Monday night.
The criticism came just one day after Trump declared that he is "not a racist" as he denied reports that he referred to Haiti and African countries as "s---hole countries."
"No, no, I'm not a racist," Trump told reporters on Sunday. "I am the least racist person you have ever interviewed. That I can tell you."
The comments were reportedly made during a closed-door meeting with members of Congress to discuss immigration on Thursday.
According to the reports, Trump also said the United States should accept more immigrants from countries like Norway.
"'I am the least racist person you have ever interviewed' seems like a ridiculous statement from Donald Trump, until you realize he was speaking to the chief reporter from the Klu Klux Kronicle," Noah said Monday evening.
He pointed out that two U.S. lawmakers claimed they personally heard Trump make the vulgar remark, but he said the president’s alleged vulgarity was not his main concern.
"Him having a poo-poo mouth is not the story for me," Noah said. "The president of the United States condemning entire groups of people as worthless and undesirable based on what country they happen to be born in, that's the story."
"I have no doubts," Schumer replied. "Donald Trump has lied so many times it's hard to believe him on anything let alone this.
"His comments over and over and over again can be described as nothing but racist and obnoxious," he added.
Schumer also presented the president with a challenge that he said would prove that he wasn't racist.
"Actions speak louder than words," Schumer said. "If you want to just begin the long road back to proving you're not racist or bigoted, support the bipartisan compromise three Democrats and three Republicans put on the floor, everyone gave, and get the Dreamers safety here in America.
"That's what he should do," he added.