What to expect from 'Grey's Anatomy' 350th episode

After numerous medical emergencies, doctor hook-ups and break-ups and devastating character deaths, ABC's "Grey’s Anatomy" is marking a very special milestone Thursday: its 350th episode.

In this installment, Ellen Pompeo's Dr. Meredith Grey has to face off against the medical board, with the future of her long career hanging in the balance -- and her past comes into play as well, ABC teases.

Actor Kevin McKidd appeared on "Live with Kelly and Ryan" Thursday to preview the "intense" episode and marvel at the show's longevity.

"It's such a blessing," McKidd, who plays Dr. Owen Hunt, joked. "I started just as we'd done a hundred episodes and back then, people were like, 'We've maybe got two more seasons.'"

"Grey's Anatomy," from creator Shonda Rhimes, debuted on March 27, 2005, and over the years it's earned 39 Emmy nominations and five wins, including an outstanding supporting actress trophy for Katherine Heigl.

Meanwhile, Pompeo, 49, has become the highest paid actress on television, with a salary of $20 million a year, plus other lucrative perks.

"I've finally gotten to the place where I'm OK asking for what I deserve, which is something that comes only with age," she told The Hollywood Reporter last year. I'm not the most 'relevant' actress out there."

"I know that's the industry perception because I’ve been this character for 14 years," she added. "But the truth is, anybody can be good on a show season one and two. Can you be good 14 years later? Now, that's a f---in' skill."