Coronavirus updates: 1st vaccines now on the way to all 50 US states

Hospitalizations in California have jumped 70% in the last two weeks and intensive care unit hospitalizations have increased by 68.7%, California Health Secretary Dr. Mark Ghaly said.

In Southern California and the San Joaquin Valley, ICU availability has fallen to 10.1% and 5.6% respectively, he said.

Gov. Gavin Newsom has ordered any region with less than 15% ICU capacity to follow a three-week stay-at-home order. In those regions, restaurants, bars and personal care services are closed.

When it comes to the holidays, Ghaly said, "We ask you to cancel travel plans."

Travel is explicitly restricted in areas under regional stay-at-home orders.

North Carolina will begin a "modified stay-at-home order" on Friday requiring residents to stay home between 10 p.m. and 5 a.m.

Restaurants, bars, and most retail stores and more must close by 10 p.m. and alcohol sales must end by 9 p.m., said Gov. Roy Cooper

"Our trends are alarming," Cooper tweeted.

"We already have strong safety protocols and capacity limitations in place -- including a statewide mask mandate," Cooper said. "With this additional action beginning Friday, we hope to get these numbers down."

The order lasts until Jan. 8.

Colorado Gov. Jared Polis' husband, Marlon Reis, was released from the hospital Tuesday after being admitted this weekend for COVID-19, the governor said.

"Marlon and I are so thankful for the doctors, nurses, and staff who took care of him," Polis tweeted.

Reis is "feeling well" and will take steroids for two more days per his doctor's recommendation, the governor's office said.

Polis, who also tested positive for COVID-19, "continues to not experience any symptoms," his office said.

ABC News' Jeff Cook contributed to this report.

President-elect Joe Biden on Tuesday outlined his top three COVID-19 priorities for his first 100 days in office: a 100-day mask-wearing program, 100 million doses of the vaccine into Americans arms in the first 100 days, and getting schools reopened permanently.

"We didn’t get into this mess quickly. We're not going to get out of it quickly," Biden said. "But I'm absolutely convinced that, in 100 days, we can change the course of the disease and change life in America for the better."

Biden warned that distributing the vaccine would be one of the hardest and costliest challenges the country will face and will require the cooperation of Congress.

“We’re gonna need Congress to fully fund vaccine distribution to all corners of the country, to everyone," Biden said. "I'm encouraged by the bipartisan efforts in Congress around a $900 billion economic relief package which I've said is critical, but this package is only a start for more action early next year."

"We'll also need the Trump administration to act now," Biden added, "to purchase the doses it has negotiated with Pfizer and Moderna, and to work swiftly to scale manufacturing to U.S. populations and the world."

ABC News' Molly Nagle contributed to this report.