Coronavirus updates: 1st vaccines now on the way to all 50 US states

Once the FDA approves the Pfizer/BioNTech vaccine, 2.9 million doses will go out immediately in the U.S., said Gen. Gus Perna, commander of the Army Materiel Command. The second batch of 2.9 million will be close behind, within 21 days, Perna said.

Twenty million Americans are expected to be vaccinated by the end of 2020, Health and Human Services Secretary Alex Azar said.

"We remain confident that across our portfolio of multiple vaccines, we will have enough doses for any American who wants a vaccine by the end of the second quarter of 2021," Azar said.

After two allergic reactions to the Pfizer/BioNTechvaccine were reported in the United Kingdom, Moncef Slaoui, Trump’s chief scientific adviser on vaccines, told reporters, "The expectation would be that subjects with known severe reaction, allergic reaction, should not take the vaccine, until we understand exactly what happened here."

ABC News' Anne Flaherty contributed to this report.

The last week marks the deadliest week for the U.S. since the beginning of the pandemic, with 15,578 deaths -- roughly equivalent to 92 deaths reported every hour.

The U.S. is now averaging more than 200,000 new cases each day -- three times higher than the country's summer peak in July, and more than six times higher than the country's spring peak in April.

There has not been a single day with less than 100,000 daily cases for the last five straight weeks, according to an ABC News analysis of data compiled by the COVID Tracking Project.

In the last week alone, the U.S. has reported 1.4 million new COVID-19 cases, more than any other week on record, and equivalent to 1 in every 231 Americans testing positive.

With numerous days now over the 200,000 mark, the seven-day average of new coronavirus cases has increased by 87% in the last month.

ABC News' Arielle Mitropoulos contributed to this report.

Pennsylvania Gov. Tom Wolf said he tested positive for COVID-19 on Tuesday and is isolating at home.

"I have no symptoms and am feeling well," Wolf said in a statement. “I am continuing to serve the commonwealth and performing all of my duties remotely."

Wolf's wife has been tested and is awaiting results.

A record 590 new fatalities were reported in Germany on Wednesday, beating the record previously set Tuesday of 568 new deaths, the Robert Koch-Institute reported.

Germany has now lost 19,932 lives to COVID-19.

"A reversal of this trend so far is not in sight," German Deputy Government spokesperson Martina Fietz said, adding that in some regions, hospitals are reaching their limits.

"With more than 4,200 people in intensive care, the number is considerably higher than in the spring," Fietz said.

Chancellor Angela Merkel spoke in parliament Wednesday, pleading with regional leaders to enforce tighter regulations to stop the spread.

Over 1.2 million people in Germany have been diagnosed.

ABC News' Christine Theodorou contributed to this report.