Omicron updates: COVID-19 cases could double in New York City

The Food and Drug Administration has authorized the first monoclonal antibody therapy for use before COVID-19 exposure. 

AstraZeneca's Evusheld antibody cocktail can now be given to certain people for preventative use against the virus, including those who are moderately to severely immunocomromised due to a medical condition or medication, and those who have a history of severe adverse reactions to a COVID-19 vaccine. People also must not be currently infected with COVID-19 or have been recently exposed to the virus.

In a recent Phase III clinical trial, AstraZeneca found that the therapy reduced the risk of developing symptomatic COVID-19 infections by 83% in people who did not have the virus, had not been exposed to it and were unvaccinated, when compared to the placebo group.

AstraZeneca told ABC News it is testing the product against the new omicron variant and is "hopeful" that it will hold up against it. Results are expected to become available "within weeks," the company said. So far, Evusheld has been found to neutralize all previous COVID-19 variants of concern, it said.

AstraZeneca said it has agreed to supply the U.S. government with 700,000 doses of Evusheld, which will be distributed to states and territories at no cost and on a pro-rata basis.

-ABC News' Sasha Pezenik

New Hampshire will be deploying National Guard members to hospitals statewide to provide support as the state sees a record number of COVID-19 hospitalizations, Gov. Chris Sununu announced Wednesday.

Seventy members will be deployed in the coming week and assist with food service and clerical work, officials said.

The Federal Emergency Management Agency will also be sending a team of 30 paramedics to help the hospitals with the highest COVID-19 burdens, the governor said.

There are 462 current COVID-19 hospitalizations in the state, the highest since the pandemic began.

The Senate passed a repeal of President Joe Biden's vaccine mandate on private businesses with over 100 employees by a vote of 52-48 Wednesday night, but the mandate is not threatened due to opposition in the Democrat-controlled House.

While the legislation has now passed the Senate, it will almost certainly not impact the mandate.

It's unclear if the Senate-passed repeal will even be brought up in the House. Speaker Nancy Pelosi is not required to bring it up for a floor vote, and at least 218 signatures would be needed to force consideration. Even then, if the House were to pass it, White House press secretary Jen Psaki said on Tuesday that Biden would veto it should it land on his desk.

The mandate faces stiffer opposition in ongoing legal challenges from several Republican-led states.

-ABC News' Allie Pecorin

Over 200 million Americans are now fully vaccinated against COVID-19, according to newly updated data from the Centers for Disease Control and Prevention.

On average, about 1.9 million shots are being administered each day, federal data shows. About half a million of those shots are first doses and nearly 1 million are boosters.

-ABC News' Arielle Mitropoulos