Mahmoud Abbas, president of the State of Palestine, is pulling out of his Wednesday meeting with President Joe Biden.

"President Mahmoud Abbas decided to return to the homeland tonight, and he called for an emergency leadership meeting tonight," a senior adviser said Tuesday.

Biden is expected to leave the U.S. Tuesday night to head to Israel and Jordan.

-ABC News' Will Gretsky

At least 500 people have been killed in an explosion at Al Ahli Arab Hospital in the middle of Gaza, according to the Gaza Health Ministry.

The hospital served as a shelter for thousands of residents who fled their homes in northern Gaza.

NaN:NaN

The Israel Defense Forces denied responsibility for the explosion, saying a failed launch by the Palestinian Islamic Jihad caused the blast.

"From the analysis of the operational systems of the IDF, an enemy rocket barrage was carried out towards Israel, which passed in the vicinity of the hospital, when it was hit," IDF said.

The World Health Organization condemned the blast and called for "the immediate active protection of civilians and health care" workers.

This hospital "was one of 20 in the north of the Gaza Strip facing evacuation orders from the Israeli military," the WHO said in a statement. "The order for evacuation has been impossible to carry out given the current insecurity, critical condition of many patients, and lack of ambulances, staff, health system bed capacity, and alternative shelter for those displaced."

Palestinian Authority President Mahmoud Abbas has declared three days of mourning following the attack.

-ABC News' Will Gretsky

Israeli National Security Adviser Tzachi Hanegbi said Tuesday that officials plan to create "safe zones" in southern Gaza as the only places where residents can receive humanitarian aid.

The aid would be "on one condition," Hanegbi said in Hebrew. "If this aid does not reach civilians, but goes to murderers, [the safe zones] will simply not exist."

The Rafah border crossing between Egypt and Gaza has now endured four bombings from Israel, according to a spokesperson for Egypt's Ministry of Foreign Affairs.

The Rafah crossing was shut on Oct. 10 after it was hit by Israeli warplanes on the Palestinian side three times on Oct. 9 and 10.

1:25

Confusion over border crossing between Gaza and Egypt

"We are in constant contact with all U.N. agencies to extract a safe passage for the relief aid," Egyptian Foreign Minister Sameh Shoukry told BBC Radio. "There is not yet any sort of authorization for a safe passage from the other side of the crossing.”

Shoukry also called out Israeli leaders who urged Gaza residents to move south, saying, "Israel’s call for displacement to the South is in full contradiction to international humanitarian law, leaving people with no water, electricity or food."

Human Rights Watch has accused Israel of using white phosphorus munitions in military operations in Gaza on Wednesday, saying it violated international humanitarian law by putting civilians at unnecessary risk.

In a report released Thursday, Human Rights Watch said it based its determination on a video it said it has verified, as well as two eyewitness accounts.

The Israel Defense Forces said in a statement to ABC News that claims they used white phosphorus in Gaza are "unequivocally false."

ABC News geolocated a video showing a jellyfish-shaped plume of white smoke over the port of Gaza. The video was posted on Wednesday by the official Palestinian news agency WAFA and matches images posted on social media and by other news outlets on the day.

1:09

Human Rights Watch says IDF used white phosphorus munitions over Gaza; IDF denies use

Two experts -- Amael Kotlarski, the weapons team manager for the defense intelligence firm Janes, and Amnesty International weapons investigator Brian Castner -- told ABC News that images suggested munitions deployed over the port of Gaza on Wednesday appeared to contain white phosphorus.

"We have verified that Israeli artillery forces striking Gaza are equipped with M825 and M825A1155mm white phosphorus projectiles," Castner told ABC News, pointing to photographs by an Anadolu Agency photographer taken on Monday and showing Israeli troops handling shells labeled "M825A1."

Kotlarski said visual evidence alone was not sufficient to confirm that these specific shells were used in the Gaza port strikes.

There are "perfectly legal" military uses for white phosphorus munitions, Kotlarski said, including to create a smoke screen to conceal movements, to mark targets for artillery or air strikes, or to illuminate a battlefield. However, its use in urban areas is "problematic due to the higher risk of collateral damage," Kotlarski said, including the munitions' potential to cause severe burns.

White House Principal Deputy Press Secretary Olivia Dalton said Friday the U.S. had not independently verified allegations Israel used white phosphorous "so that is not something I would want to speculate about or weigh in on at this time."

-ABC News' Christopher Looft, Ben Gittleson and Jordana Miller