Israel-Gaza updates: Netanyahu says Israel 'can't be flexible' on some issues

President Joe Biden addressed the rising tensions in the Middle East Tuesday after U.S. officials warned Iran could launch a retaliatory attack on Israel as early as "this week."

Biden told reporters he expects Iran to hold off on carrying out a retaliatory attack against Israel if a cease-fire deal with Hamas is reached.

"That’s my expectation, but we’ll see," Biden said after arriving in New Orleans, LA.

Last week, Biden along with the leaders of Egypt and Qatar jointly called for Israel and Hamas to return to the negotiating table and reach an agreement that would free hostages and end the war in Gaza.

Hamas leaders declined the new set of cease-fire conditions on Sunday, asking for negotiations to resume around what was presented in July.

-ABC News' Justin Gomez

The U.S. State Department has signed off on several large arms transfers to Israel, notifying Congress on Tuesday that it has approved the sale of more than $20 billion worth of weaponry and military equipment.

All of the sales surpass the value threshold that requires the State Department to formally notify Congress 15 days before initiating the transfer process. Congress can move to reject the transaction by adopting a joint resolution of disapproval within that timeframe.

Some of the items aren’t scheduled to arrive in Israel for years.

-ABC News' Shannon K. Kingston

Israeli forces killed two Hezbollah fighters from its Southern Front on Tuesday, the Israeli Defense Forces said in a statement. Hezbollah has confirmed the death of two of their fighters on Tuesday.

These attacks come as Israel awaits a response from Hezbollah and Iran for killings in recent weeks.

Several U.S. officials are headed to the Middle East this week in a bid to de-escalate regional tensions and try to salvage hostage negotiations, as the window for a deal appears to be closing.

CIA Director Bill Burns is expected to arrive in Doha, Qatar, this week, where he will lead a crucial meeting on the hostages, according to a U.S. official. It’s not clear, however, whether a representative of Hamas will attend.

Meanwhile, Brett McGurk, Biden’s top adviser on the Middle East at the White House, was expected to travel separately to Cairo, according to the U.S. official.

Axios first reported the travel plans for Burns and McGurk, noting that McGurk’s plan was to nail down a security plan for the Egypt-Gaza border.

The diplomatic trip also comes as the U.S. has been scrambling to revive a coalition of countries that helped to defend Israel last April during an attack by Iran.

Israel has been bracing for Iran to launch a retaliatory attack following the assassination of a senior Hamas official in Tehran.

The U.S. official acknowledged "there have been complications" with getting some of the Arab countries on board but added they've been "able to put in place preparations" to defend Israel successfully.

-ABC News' Anne Flaherty