Trump made the remarks from his Mar-a-Lago resort in West Palm Beach, Florida.
Here is the full transcript of his remarks:
My fellow Americans, on Tuesday, Syrian dictator Bashar al-Assad launched a horrible chemical weapons attack on innocent civilians.
Using a deadly nerve agent, Assad choked out the lives of helpless men, women and children.
It was a slow and brutal death for so many -- even beautiful babies were cruelly murdered in this very barbaric attack.
No child of God should ever suffer such horror.
Tonight I ordered a targeted military strike on the airfield in Syria from where the chemical attack was launched.
Years of previous attempts at changing Assad's behavior have all failed and failed very dramatically.
As a result the refugee crisis continues to deepen and the region continues to destabilize, threatening the United States and its allies.
We ask for God's wisdom as we face the challenge of our very troubled world. We pray for the lives of the wounded and for the souls of those who have passed. And we hope that as long as America stands for justice, then peace and harmony will -- in the end -- prevail.
Goodnight, and God Bless America and the entire world.
ABC News' Arlette Saenz contributed to this report.