The famed international human rights lawyer told the BBC that she is "perplexed" by the Republican presidential front-runner's statements about women.
Clooney, who is married to the actor George and hosted a California fundraiser for Hillary Clinton with him earlier this month, specifically cited an anti-Trump ad that features women reciting comments he has made about other women in the past.
When asked what she thinks about his comments about women and why he is doing so well in the polls, Clooney said, "I have to say I'm probably as perplexed as you are."
"He has a really high negative rating and I don’t think he’s going to get much of the women’s vote as a result of that. And I think, ultimately, we are still dealing with a primary season and not the full election, and so if at the end of all of this he gets beaten by the person who becomes the first female president of the United States, I think that would send a very positive message from the electorate back to him as to what they really think of those points of views," Clooney said.
She also took issue with the comments Trump has made about Muslims, who he suggested should be temporarily banned from entering the country.
"When you listen to what the leading candidate on the Republican side has been saying about building walls, about excluding Mexicans, and saying, you know, there has to be a complete shut down on all Muslims entering … he kept saying 'they' only want jihad, 'they' don’t believe in our way of life, 'they' don't respect our system,” she said.
“And when he says 'they,' and you watch the media coverage afterward, people I think should have been saying, do you mean the 1.5 billion people around the world who fit that description? Do you mean the people who are U.S. citizens who are members of your military, who are the vast majority of whom are not extremists or violent in any way?"