"It's everybody's deepest hope that justice at last can be properly delivered. Hillary has nobody to blame but herself for her mounting legal troubles. Her criminal action was willful, deliberate, intentional and purposeful," he said.
The FBI, in its initial assessment of Clinton's handling of emails during her tenure as secretary of state, declined to prosecute. Trump had long derided the FBI for its decision, and Saturday he speculated that the recent decision occurred because of a "revolt" within the organization.
"These are great, great people, great men and women, people that love our country. I want to tell you, I'll bet you, without any knowledge, there was a revolt in the FBI, there was a revolt in the FBI with what they let happen with respect to Hillary Clinton," he said. "There was a revolt. I can be pretty sure of it."
Trump also took advantage of the news to mount a new attack on one of his longtime targets -- Anthony Weiner, Abedin's husband.
"If you check out the tweets or if you check out whatever it is I wrote about him, it was so perfect," Trump said. "They found, by looking at Anthony Weiner -- a major, major, major sleaze -- they found what may be some of the 33,000 missing and deleted emails."
Trump went on to speculate about whether Clinton would fire Abedin, who is separated from Weiner.
"I wonder, is she going to keep Huma. Does everybody agree. I wonder if Huma is going to stay there?" he asked. "And I hope they haven’t given Huma immunity."
Trump has long feuded with Weiner. During a news conference in July, Trump said that Weiner's marriage to Abedin made him uncomfortable.
"I mean, her number one person, Huma Abedin, is married to Anthony Weiner, who's a sleazeball and a pervert. And I'm not saying that -- I mean, that's regarded history, right? I don't like Huma going home at night and telling Anthony Weiner all of those secrets, OK?"
Trump has feuded with Weiner on Twitter for years.
ABC News’ Mike Levine contributed to this report.