All eyes are now on Lt. Gov. Kathy Hochul, the woman who will succeed Cuomo on Aug. 24.
Hochul, 62, will be New York's first female governor in the state's history.
Hochul, who chaired the governor’s "Enough is Enough" campaign to combat sexual assault on college campuses, tweeted a statement following Cuomo's announcement, stating his decision to step down was "the right thing to do and in the best interest of New Yorkers."
"As someone who has served at all levels of government and is next in the line of succession, I am prepared to lead as New York State’s 57th governor," she said.
Hochul will serve the remainder of Cuomo's term, which ends next year. She has not indicated if she will run again. New York faced a similar change in power in 2008 when David Paterson assumed the office following Gov. Eliot Spitzer's resignation over a prostitution scandal.
Hochul, who has been in her position since 2015, has had a long history with New York state politics.
Born in Buffalo, New York, Hochul earned a B.A. degree from Syracuse University in 1980 and a J.D. from Catholic University four years later.
After graduating from law school, she worked for a private Washington D.C. firm before serving as legal counsel and legislative assistant to U.S. Rep. John LaFalce and later U.S. Sen. Daniel Patrick Moynihan, according to her official New York state bio.
In 1994, Hochul was elected to the Hamburg Town Board in Erie County, New York, and served until 2007 when she was appointed the Erie County Clerk.
"She served as liaison to the local economic development agency and worked to attract new businesses and create jobs following the loss of the [Western New York] manufacturing base," her bio said.
During her time in office, Hochul also worked to help displaced women. In 2006, she, her mother and her aunt established the Kathleen Mary House, a transitional home for victims of domestic violence.
In 2011, Hochul was elected to the U.S. House of Representatives in a special election for New York's 26th district. Chris Collins would defeat her in the 2012 election.
During her tenure, she sat on the Armed Services and Homeland Security committees.
Cuomo nominated Hochul to be his lieutenant governor when he successfully ran for his second term in 2014. Cuomo and Hochul won re-election in 2018.
Under the Cuomo administration, Hochul has overseen several state projects and governing groups. She chairs 10 regional economic development councils, which help decide investments for projects in New York and the State Workforce Investment Board.
Cuomo appointed her as co-chair of the Heroin and Opioid Abuse Task Force.