The demonstrators -- some of whom are doctors, nurses, health care aides and patients with chronic health conditions -- crowded around the offices and refused to leave, prompting the U.S. Capitol Police to physically remove them from the site. Organizers said demonstrators came from 21 U.S. states.
Over 100 protesters were arrested, but no senators were present during the demonstrations.
"We're not just here representing ourselves. We're here for women, for children, for indigenous people, for poor people. We're just trying to get our message across. This is our reality. This is not their reality show," said Nanti Ortiz, a protester from Arizona.
“My care was paid for by an insurance company. Without the protections of ACA, I would not have access to that care because I have a pre-existing condition,” she said, while participating in the sit-in in Portman's office.
Peter, from Cleveland, detailed the $90,000 bill he received from emergency surgery and said “Senator Portman, do the right thing. Kill the bill. Don't kill me.”
Others within Portman’s office made desperate pleas over cuts to Medicaid.
The bill would also take away health insurance coverage from 22 million Americans, and is estimated to create $541 billion in tax breaks for the wealthy and corporations.
Housing Works, Center for Popular Democracy and their affiliates including People’s Action, Rights & Democracy Vermont and Arizona-based LUCHA took responsibility for collaborating with a nationwide network of activists to organize today’s protests.
“Senators should go on notice: if you pass a bill that repeals Obamacare and takes health care from millions of people, we will make sure you lose your job," Jennifer Epps-Addison, Co-Executive Director and Network President for Center for Popular Democracy said in a statement.
The bill only requires two senators to vote against it to fail.
ABC News’ Ali Rogin contributed to this report.