Streep, donning an American flag dress, followed Bill Clinton's speech with an enthusiastic scream. She spoke about what it took to be the first woman to make history as a major party nominee, referencing Clinton's drive to become the first female president.
"It takes grit and it takes grace," she said.
Comparing Clinton to other women who fought to make history, Streep said, "that's Hillary... that's America."
She introduced a video that compared Clinton's run for the presidency to other important moments in American history.
Banks acted as master of ceremonies, and mocked Trump, parodying the way he emerged on stage last Monday at the RNC in Cleveland.
Ferrera appeared on stage with Dunham and said that Trump would "make America hate again," stressing the dangers that they said he would pose to Latinos and women.
Keys closed the night with a performance of her single "Superwoman," which she dedicated to mothers who have lost their sons to gun violence.
"Here in this moment... for us," Keys tweeted before going on stage to perform.