Playing for the first time in a year since the 2019 season-ending elbow injury sustained in Week 2, Roethlisberger completed 21 of 32 passes for 229 yards and 3 touchdowns - and an 11-yard keeper for a first down.
With his third touchdown pass of the night - and second to JuJu Smith-Schuster, Roethlisberger notched his 366 career touchdown, setting a franchise record and tying Eli Manning for eighth-most in NFL history.
"I am just so excited, I am just thankful," Ben Roethlisberger told ESPN's Maria Taylor in his postgame interview. "I told the guys in the locker room before the game that I'm back because of them. I don't need to accomplish anything personally anymore. It's about being with a defense that I think is as good as any I have ever played with, skill guys that are young and fun to play with and then, of course my line, who I love to death and they love me.
"They are the reason I came back to play."
It wasn't the most auspicious start for Roethlisberger, 38, when he threw up a lateral to James Conner under pressure for no gain, ending his first series back after three plays. But Roethlisberger slowly got into a rhythm, finding Smith-Schuster for an 11-yard gain on the next series. That gave the quarterback and his offense a little life as he went on to connect with rookie Chase Claypool on a 28-yard toe-tapping reception to convert a third-and-long. The Steelers had to settle for a field goal on that drive, but a quarter later, Roethlisberger found the end zone when he hit Smith-Schuster for a 10-yard touchdown, capitalizing on T.J. Watt's interception of Daniel Jones in Giants' territory.
Roethlisberger looked most like his old self in an abbreviated two-minute drill just before halftime, leading the Steelers on an eight-play, 78-yard drive capped with touchdown throw to James Washington where the third-year wide receiver muscled his way into the end zone for the score. Just before that drive, Roethlisberger stood on the sideline between drives with a jacket transformed into a wrap for his surgically repaired elbow to keep him loose and warm.
After a scoreless third quarter, Roethlisberger got his team on the board yet again with a field-goal drive followed by a long 11-play, 75-yard drive finished with Smith-Schuster's second touchdown to seal the victory on his return.
The veteran quarterback did it with a new-look offensive line, including an entirely different right side than the one he last played behind. Zach Banner won the right tackle job out of training camp, while Stefen Wisniewski replaced the injured David DeCastro at right guard. But both left late in the fourth quarter with a knee injury and pectoral injury, respectively.
The Steelers also finished the game without starting running back James Conner, who was ruled questionable to return with an ankle injury late in the fourth quarter, but didn't play after early in the second.