Coming Up: HHS Secretary Kathleen Sebelius & Senate Minority Leader Mitch McConnell

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The White House sets a deadline for health care reform. The President said it's time to "bring this journey to a close." Will Democrats go it alone? Do they have the votes? Can concerns over abortion funding be resolved?

Guest anchor Matthew Dowd puts those questions to Health and Human Services Secretary Kathleen Sebelius.

Then, a 'This Week' Exclusive with Senate Minority Leader Mitch McConnell. He warned Democrats to pass health care reform at "your own peril".

What is the Republican strategy to defeat health care reform? Will Republicans make it the defining issue in the midterm elections?

Plus our roundtable, George Will, Democratic political strategist Donna Brazile, Republican political strategist Torie Clarke and former Clinton Labor Secretary Robert Reich take on the health care debate.

And, more political problems for New York Democrats as Congressman Charlie Rangel gives up his Ways and Means gavel amid ethics troubles, pressure builds for Governor Paterson to resign and another New York Congressman bows out after sexual harassment allegations surface.

New employment numbers show a rocky recovery – when will jobs bounce back? And break out the popcorn for the roundtable's Oscar picks.

You won't want to miss it.