The Chicago Transit Authority bus was turning off Lake Street where it intersects with Michigan Avenue, collided with four cars and came to a stop on a pedestrian plaza, ABC station WLS in Chicago reported.
Cook County Medical Examiner's Office spokesman Frank Shuftan said Northwestern Memorial Hospital reported that one of the people brought there after the crash died.
The bus driver was later ticketed for failing to stop at a red light and failing to exercise due care, Chicago Police told ABC News.
The crash involved the bus and four cars, and the bus driver and a pedestrian were taken to hospitals in critical condition, according to the fire department spokesman, Joe Roccasalva. The bus driver's condition was later upgraded to stable to good condition.
Six other people taken to the hospital in serious condition and one, a pediatric case, was in good condition, Roccasalva said.
Authorities said that there were no passengers on board the bus at the time of the crash.
Individuals injured in the crash were taken to several different hospitals, including Northwestern Memorial Hospital, St. Joseph Hospital, Lurie Children's Hospital and Mercy Hospital, according to Roccasalva.
Michigan Avenue was shut down for two blocks in each direction from the crash.