"This thing's coming," he warned. "It looks like it's going to go right through the middle of our state."
Mandatory evacuation orders have been issued for Florida's barrier islands, coastal communities and low-lying areas across Florida, including Brevard, Broward, Charlotte, Collier, Flagler, Glades, Hardee, Hendry, Indian River, Lee, Manatee, Martin, Miami-Dade, Monroe, Palm Beach, Pinellas, Sarasota and St. Lucie counties.
Scott, who declared a statewide emergency earlier this week, has also ordered all public schools, including state colleges and universities, to be closed Friday through Monday so those buildings can be used for shelters. State offices will also be shuttered.
"It's a massive storm; it can be devastating," Scott said of Irma, which is expected to make landfall as a Category 4 hurricane in southern Florida early Sunday morning.
"I'm a father, I'm a grandfather, I love my family," the governor added. "I hope every parent in this state and grandparent is thinking, 'How do I protect my family?'"
Scott said Irma could be worse than Hurricane Andrew, which devastated the Bahamas and Florida in August 1992.
If Florida residents are unsure how to evacuate ahead of Irma, Scott said to call the state emergency hotline or go online to www.floridadisaster.org.