Francine updates: Storm pushes across South as tropical depression

With hours to go until Hurricane Francine makes landfall in Louisiana, "the time to evacuate has now passed," Jacques Thibodeau, the director of the Governor's Office of Homeland Security and Emergency Preparedness, said at a news conference.

"It is now time to go down and hunker down," he said. "We are no longer in the, 'Prepare for a hurricane' -- we are now in the, 'Respond to a hurricane.'"

The White House has approved an emergency declaration for the state. The Louisiana National Guard expects to have 2,400 guardsmen ready for the storm, along with 58 boats, 101 high water vehicles and 61 aircrafts, officials said.

Louisiana Gov. Jeff Landry said he’s been in contact with the Federal Emergency Management Agency and the Army Corps of Engineers, and said he’s fully confident in all state and federal agencies working together before, during and after the hurricane.

Landry also encouraged residents to “take advantage of the power that you have currently and make sure that you charge all of your devices.”

-ABC News’ Alexandra Faul

Residents in New Orleans should stay off the roads beginning at noon ET and remain sheltered in place until Thursday morning, Mayor LaToya Cantrell said.

"Conditions will worsen throughout the day—stay safe!" she tweeted.

Francine is churning north as a Category 1 hurricane with 90 mph winds.

Landfall is forecast Wednesday afternoon or early evening as a Category 1 hurricane near Houma, Louisiana.

Life-threatening storm surge, flash flooding and hurricane-force winds are bearing down on Louisiana.

The storm surge could reach 10 feet along the Louisiana coast and wind gusts could hit 70 mph in New Orleans.

"Ensure you are in a safe location before the onset of strong winds or possible flooding," the National Hurricane Center warned.

By Thursday morning, Francine will be bringing rain and gusty winds to Mississippi, and potential tornadoes to Alabama and the Florida Panhandle.

Throughout the day Thursday, the heavy rain and tornado threat will move into northern Alabama, Mississippi and Tennessee. Flash flooding is possible near Memphis and Nashville.

-ABC News’ Max Golembo

A raft of warnings was issued for cities in Louisiana, Mississippi and Alabama ahead of Hurricane Francine’s expected landfall on Wednesday afternoon.

A hurricane watch was issued for New Orleans, with hurricane warnings for Morgan City and Houma on Louisiana’s Gulf Coast.

Tropical storm warnings are in place further east, covering cities including Biloxi, Mississippi, and Mobile, Alabama.

Storm surge warnings were announced for both Biloxi -- where water may rise up to 5 feet -- and Mobile, where water levels may rise by up to 4 feet.

Francine is expected to make landfall as either a high-end Category 1 or low-end Category 2 hurricane, with winds between 90 and 100 mph, the National Hurricane Center said. The Category 2 classification begins with winds of 96 mph.

Landfall may bring tornadoes in areas around New Orleans, Biloxi, Mobile and Pensacola, Florida.

Heavy rain may cause flash flooding from New Orleans all the way up to Jackson, Mississippi through to Wednesday night. As the storm moves into Mississippi on Thursday, it is forecast to produce flash flooding and gusty winds.

Francine is expected to stall through Thursday night into Friday morning, bringing heavy rain to Memphis, Nashville and Paducah, Kentucky.

-ABC News’ Max Golembo