Hurricane Helene live updates: 52 killed, including mom and her twin infant sons

President Joe Biden said in a statement that he is "deeply saddened by the loss of life and devastation" caused by Hurricane Helene.

"As the storm continues to track north, Vice President [Kamala] Harris and I remain focused on life-saving and life-sustaining response and recovery efforts," Biden said.

He also said that he will be with affected Americans "every step of the way" during recovery efforts.

"We will make certain that no resource is spared to ensure that families, businesses, schools, hospitals, and entire communities can quickly begin their road to rebuilding," Biden said.

-ABC News’ Michelle Stoddart

Georgia saw a historic 11 inches of rainfall from the combination of Hurricane Helene and a storm earlier in the week.

Helene sparked flash flooding and mudslides, and destruction includes crumbled buildings, fallen trees and downed power lines, officials said.

From the air, Gov. Brian Kemp said the damage "looks like a bomb went off."

Seventeen people have been killed from Helene in Georgia and officials warned "that number will most likely climb as a result of … the cleanup process, due to dangerous situations."

Georgia Power CEO Kim Greene said Helene caused "an unprecedented level of damage." Compared to last year’s Hurricane Idalia, she said Helene caused more than double the amount of damage to the company's distribution system, and significantly more to the transmission system, complicating restoration efforts.

Officials are urging residents to stay off the roads.

"Be patient, help your neighbor, and thank these first responders," Kemp said.

At least 52 people have died from Hurricane Helene, according to The Associated Press. Fatalities were confirmed in Florida, Georgia, South Carolina, North Carolina and Virginia.

In Georgia, the 17 victims killed include Leon Davis, an assistant fire chief from Blackshear, who died when a tree fell on his car while he was responding to a call, officials said. Also killed in Georgia was a 27-year-old mother and her 1-month-old twin boys, who died when a tree fell on their home in Washington County, officials said.

In Florida, the death toll has climbed to 11, Gov. Ron DeSantis announced Saturday.

At least 17 were killed in South Carolina, including two firefighters in Saluda County, Gov. Henry McMaster said.

More than 4 million customers lost power across the South on Friday in the wake of Hurricane Helene, and on Saturday morning, more than 2 million are still without power.

More than 1 million are without power in South Carolina and 400,000 customers are in the dark in Florida.

Over 700,000 are without power in Georgia, another 600,000 customers are without power in North Carolina and more than 100,000 are in the dark in Virginia.

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Hurricane Helene knocks out power to millions of residents across the Southeast

Nearly a half a million customers are still without power. Duke Energy State President in Florida, Melissa Seixas, describes some of the challenges crews face as they try to restore power.