Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
Tampa International Airport will stop all operations starting 5 p.m. Tuesday to secure its airfield and terminals ahead of Hurricane Ian's expected landfall later this week.
The U.S. Department of Health and Human Services has declared a public health emergency for the state of Florida.
HHS Secretary Xavier Becerra made the declaration Monday to address the possible health impacts for Florida residents once Hurricane Ian nears the state.
"We will do all we can to assist Florida officials with responding to the health impacts of Hurricane Ian," Becerra said in a statement. "We are working closely with state, local, and tribal health authorities, as well as our federal partners, and stand ready to provide additional public health and medical support."
HHS has pre-positioned two 15-person health and medical task force teams from its National Disaster Medical System, as well as a 13-person incident management team and two pharmacists to assist with the response in Florida.
"These teams are highly trained and ready to respond if, when, and where they may be needed following the storm," HHS Assistant Secretary for Preparedness and Response Dawn O’Connell said.
Florida Gov. Ron DeSantis declared a state of emergency on Saturday. That declaration was approved by President Joe Biden on Sunday.
The National Hurricane Center has issued a hurricane warning for the Tampa Bay area just after its 5 p.m. advisory for Hurricane Ian.
The hurricane, currently a Category 2, is forecast to strengthen before it slows down as it approaches land. It is then expected to hover off the coast of Tampa from Wednesday into Thursday before making landfall.
A hurricane watch has also been issued for Big Bend, Florida, near the panhandle, and tropical storm warnings are in effect for much of southwest Florida.
Tropical storm watches are in effect for Orlando toward the northeast portion of the state, from Fort Pierce to Jacksonville.
-ABC News' Melissa Griffin
The emergency response from Florida Power & Light is “well underway” as Hurricane Ian approaches, the utility company announced Monday.
FP&L has mobilized 13,000 workers, as well as supplies, to ensure the response is conducted as safely and quickly as possible after the storm hits, according to a press release.
As the hurricane begins to bear down on the region, FP&L will use remote grid technology to restore power remotely during the storm, as long as it is safe to do so, the company said. After the storm passes and winds drop below 35 mph, FP&L will continue restoration and conduct damage assessments with field crews.
The utility company also urged customers to make preparations and take safety precautions.
"As this storm approaches Florida, we know our customers are counting on us and we are determined to meet this challenge," said Eric Silagy, chairman and CEO of FP&L in a statement. "We are mobilizing and pre-positioning our restoration workforce, so these brave men and women can quickly start working as soon as it is safe to do so."
-ABC News' Matt Foster
