Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
As Ian moves north over Florida, tropical storm force winds will reach coastal Georgia and South Carolina.
Tropical storm watches have been issued for Savannah and near Charleston.
Georgia Gov. Brian Kemp has issued a state of emergency.
Ian, now a Category 3 hurricane with 120 mph winds, has strengthened on Tuesday and is forecast to strengthen even more into the night.
The latest track shows Ian making landfall on Wednesday, striking the west coast of Florida between Tampa and Fort Myers, bringing flooding and damaging winds.
Hurricane warnings are in effect from Tampa to Fort Myers and storm surge warnings are in effect for a large portion of Florida’s west coast.
There is also a risk for tornadoes in Florida Tuesday and Wednesday.
Federal Emergency Management Agency Administrator Deanne Criswell warned Tuesday, "Floridians are going to experience the impacts from the storm for a very long time."
"Our biggest concern as we wait for this storm to make landfall is storm surge," Criswell said. "In 2018, when Hurricane Michael impacted the Florida Panhandle, there were five recorded fatalities as a result of storm surge. So therefore, if people are told to evacuate by their local officials, please listen to them. The decision you choose to make may mean the difference between life and death."
President Joe Biden on Tuesday urged residents to "evacuate when ordered."
Biden said he spoke to the mayors of Tampa, St. Petersburg and Clearwater Tuesday morning and told them to "contact me directly" for "whatever they need."
Criswell said a search and rescue coordination group has been activated, including members from FEMA's urban search and rescue teams, the Coast Guard, the Department of Defense and the Department of the Interior.
The Red Cross has established 29 shelters and is prepared to open 60 more shelters if needed, she said.
Criswell stressed, "To those who may be watching at home, get ready and do not underestimate the potential that the storm can bring."
The Orlando International Airport said operations will stop at 10:30 a.m. Wednesday.
The St. Pete-Clearwater International Airport is closing at 1 p.m. Tuesday while Tampa International Airport is suspending flights at 5 p.m. Tuesday.
The Sarasota Bradenton International Airport is closing at 8 p.m. Tuesday while the Melbourne Orlando International Airport will stop flights at 2 p.m. Wednesday.
