Gov. Gavin Newsom said 7,500 firefighters are deployed to battle the fires.
At least five people are dead and many more injured as several fires broke out across Southern California amid historically dry and windy conditions.
Thousands of firefighters are battling at least five major wildfires dotted around the Los Angeles area, as well as several smaller blazes. Thousands of structures have been damaged or destroyed and more than 100,000 people evacuated.
The California Department of Forestry and Fire Protection listed five major active wildfires spread around the Los Angeles area as of Wednesday night.
The Palisades Fire began in the Pacific Palisades area of the city on Tuesday. It has so far burned 17,234 acres and is at 0% containment. More than 1,000 structures have been damaged or destroyed.
The Eaton Fire north of Pasedna began on Tuesday. It expanded to 10,600 acres and is at 0% containment. Up to 500 structures have been damaged or destroyed.
The Hurst Fire in Sylmar, northwest of San Fernando, began on Tuesday and has burned 855 acres. It is at 10% containment.
The Lidia Fire erupted on Wednesday on the northwest edge of the Angeles National Forest. It has grown to 348 acres and is at 40% containment.
The Sunset Fire broke out above West Hollywood on Wednesday. It is at 43 acres and 0% containment.
The Eaton Fire has spread to 10,600 acres with 0% containment, according to the U.S. Forest Service.
At least two residents have been reported dead due to the fire. Officials are urging residents to follow evacuation orders.
Twenty-two of Los Angeles County's 80 school districts are closed Wednesday due to fires and weather conditions in the region, according to the Los Angeles County Office of Education.
These school districts are reporting closures, according to the office:
Additionally, several schools in the Los Angeles Unified School District are closed, officials said.
California Gov. Gavin Newsom canceled his trip to Washington D.C., for former President Jimmy Carter's memorial service amid the continued spread of multiple fires in Southern California.
President Joe Biden spoke to Newsom by phone on Wednesday to "receive the latest update on the wildfires across Los Angeles." Biden is still expected to get a briefing later from Cal Fire officials.
FEMA Administrator Deanne Criswell also spoke with Newsom to get an update on the wildfires, according to a FEMA spokesperson. FEMA's regional office in California is in constant communication with California Office of Emergency Services and the agency has deployed a FEMA liaison to their offices as the agency continues to monitor the situation closely.
The regional administrator for FEMA Region IX approved Fire Management Assistance Grants for the Palisades Fire to support the state with the control of the fires.
Vice President Kamala Harris' Los Angeles neighborhood is under an evacuation order, according to her office.
No one was in the home at the time, Ernie Apreza, a spokesperson for her office, said.
"She and the Second Gentleman are praying for the safety of their fellow Californians, the heroic first responders, and Secret Service personnel," Apreza said on X.
Harris and her husband, Doug Emhoff, own a home in Brentwood, which Emhoff purchased in 2012 for $2.7 million.
-ABC News' Molly Nagle
