According to FlightAware.com, 2,496 flights have been cancelled across the country today, on top of the more than 2,500 that were cancelled Monday due to weather.
As it moves up the coast, weather forecasters said it will combine with snow from the Midwest, bringing eight to 16 inches of snow in some areas, particularly in New England and New York's Long Island.
"It will be intensifying rapidly later today and tonight as it moves north," National Weather Service Meteorologist Christopher Hedge told ABC News Radio. "And some heavy snow will be moving into the Mid-Atlantic and the Northeast, especially along the I-95 corridor from New Jersey all the way up through Boston."
Watch "World News with Diane Sawyer" for the latest on the weather tonight on ABC.
Snow is expected to arrive tonight and into the overnight with the heaviest snow to fall east of New York City.
The New York City Department of Emergency Management cautioned the public to avoid unnecessary driving during the storm.
Boston has declared an even more severe snow emergency and will be under a blizzard warning from 2 a.m. to 8 p.m. on Wednesday.
It's the third time since Christmas a snowstorm has targeted the Northeast. Connecticut resident Denise Creacy says it's too much.
"I need a break, but everybody's getting it. My brother's from Atlanta and he texted me. He goes, 'It shut down the city we have six inches,' " Creacy told ABC News Radio. "'I'm like, six inches? What's that.' Get your broom, you'll be fine."
From the Carolinas to Georgia to Tennessee, Southeast residents face lingering problems as authorities work to restore power and commuters drive on ice-covered roads.
The storm dropped about 15 inches of snow in parts of Jackson County, N.C., Monday.
Pete Hutchinson was shoveling about a foot of snow at his gas station in Waynesville so he could open for business.
"Just trying to get shoveled out so we can make some money," he said. "Not good for business, but it sure is pretty."