Antihistamine Looks Promising for Alzheimer's Patients

Clinical trials of a new drug show improvement in patient memory.

ByABC News
July 17, 2008, 3:22 PM

July 17, 2008— -- Alzheimer's disease can be heartbreaking to watch and frustrating to treat. Most medicines on the market do little more than delay the inevitable mental decline.

But a new drug called Dimebon appears to stop and perhaps even reverse the symptoms of the cruel and degenerative disease, according to a new study published in the journal Lancet today.

"I was pleasantly surprised to see the effect on cognitive function, on memory, on activities of daily living that not only were clearly significant but seemed to increase over time," said Dr. Sam Gandy, former chairman of the Alzheimer's Association Medical and Scientific Advisory Council.

Dimebon wasn't designed to treat Alzheimer's disease. Far from it. It's an antihistamine that was supposed to treat allergies.

But a study that tracked 120 mild to moderate Alzheimer's patients for a year, and found that at six months those taking Dimebon three times a day showed significant improvement in mental tests and cognitive functioning, while those placed on the placebo kept deteriorating. A year into the study, the Dimebon group was still improving, while those without the drug were declining rapidly.

What's most encouraging for researchers is that current Alzheimer's drugs lose their effectiveness after three or six months. But Dimebon still worked after at least a year and seemed to be improving with time.

For those five million Americans living with Alzheimer's disease, memories tend to be lost first and then its victims lose the ability to care for themselves.

Currently, there is no cure for Alzheimer's, so eventually, they lose their lives. Those with Alzheimer's in the moderate to severe stages often lose the ability to complete daily tasks, such as dressing themselves, walking and eating.

Karen Henes, 62, of Croton-on-Hudson, N.Y., was diagnosed with Alzheimer's just a year ago, and already complains of some such symptoms.

"I would like to just go see my grandchildren. I can't," Henes said. "I'm not responsible enough just to drive. I can't always remember what to do. It's really sad."

Her husband Michael expressed equal frustration with the disease.

"Life with Karen is so frustrating. It has already changed," he said. "She writes down all her appointments and she still doesn't remember them. On a day-to-day basis, it's a struggle."