If stardom came early to Drew Barrymore, so did addiction. Barrymore, now 33, has admitted that she had her first drink at age 9, began smoking marijuana at 10 and took up cocaine at 12. By the time she turned 13, she had undergone extensive drug rehab -- twice.
Acting and addiction appear to be part of Barrymore's lineage. Her grandfather John Barrymore, a star of the stage and screen in the '20s and '30s, drank himself to death at age 60. Her aunt Diana Barrymore detailed her love for booze and drugs in the 1957 best-seller "Too Much, Too Soon."
And her father, John Drew Barrymore, a sometime actor and poet who never lived with her, had a history of alcoholism and drug arrests.
After a period in her late teens of appearing nude in Playboy and making five films, Barrymore cleaned up her act, choosing a successful string of romantic comedies, becoming a Cover Girl model and getting involved with a U.N. charity.
But this summer, after her breakup with actor Justin Long, the tabloids speculated that Barrymore may have resumed her love affair with booze.
"Justin got tired of having to help Drew to the car at the end of the night," an unnamed source told the National Enquirer. "Justin gently suggested to Drew that they both slow down on the drinking, and she didn't take it well. Her inability to accept Justin's advice became the deal breaker."
Liza Minnelli and Judy Garland
It seems that for most of her life, Liza Minnelli has been trying to escape the shadow of her mother, Judy Garland.
Not only did she inherit her mother's talent for singing, dancing and acting, but she also inherited her mother's addictions to drug and drink. Garland died from an overdose at 46. Minnelli became a star in her own right but also succumbed to the darker forces of her mother's personality.
After waiting until 30 to sip her first drink, Minnelli fell deeply into booze and drugs in the hard-partying '70s. By 1984, her half-sister Lorna Luft was forced to literally kidnap Minnelli to save her from a downward spiral of alcohol, cocaine and pills. Luft wrote in her 1988 memoir, "Me and My Shadow," of how Frank Sinatra loaned her his plane to fly Minnelli to the Betty Ford Clinic in California.
She has returned to rehab a handful of other times since then, including in 2003, when she checked herself into an eight-week "self-help" program, according to Reuters.
During a 2006 interview on "The Actor's Studio," Minnelli tried to explain how she had succumbed to the same demons she had once seen her mother wrestle.
"Nobody would do that, if they had seen the things that I had seen -- unless they couldn't help it," Minnelli said. "I've won three Tonys, an Academy Award, three Golden Globes … a lack of willpower, I don't think so. This is a disease and the sooner we know that, the better."
Mackenzie Phillips and father John Phillips
It almost seemed like Mackenzie Phillips' battles with drugs were behind her. The "One Day at a Time" star saw her career, which had skyrocketed in the 1970s and '80s, suspended when she suffered two near-fatal overdoses, went through rehab several times and repeatedly relapsed.
She returned to television in the 1990s, playing a counselor on the original "90210," and recently she played a rock star mom in the Disney Channel series "So Weird."