Numerous media outlets, including "Today," "Late Night With Jimmy Fallon" and ABC News Now's "What's the Buzz," were left scrambling for guest replacements after all of his media appearances for the day were cancelled.
The 73-year-old actor, photographer and director said he woke up early this morning vomiting, Starz publicist Lindsay Gallagher told ABC News.
"He feels terrible for cancelling, but I think it's for the best," said Gallagher.
The star of "Easy Rider" and "Blue Velvet" was taken to New York Hospital Wednesday afternoon for treatment.
His current project, "Crash," is a TV version of the Oscar-winning 2004 film. In the drama series, Hopper plays the role of a maniacal music producer, Ben Cenders.
The Associated Press contributed to this report.