"It's driving me a little crazy," she noted, laughing.
Streisand records her music in a home on her property called "Grandma's House."
When she not satisfying her creative outlets, Streisand works to save women from heart disease.
"I was so shocked by that fact that heart disease in women kills more women than all cancers combined. That's why I've funded … my educational research department at (Cedars-Sinai Medical Center) for the Women's Heart Center, to promote healthy hearts," she said.
Click HERE to learn more about the Cedars-Sinai Women's Heart Center.
Streisand said her work is inspired by her father, an educator and scholar who died at 35.
"There was so much he wanted to write. There was so much he wanted to do. And he never got to do it. So maybe I'm somehow doing it for him," she said.
See more of the interview with Barbra Streisand tonight on "Nightline" at 11:35..