They had no problem making "Friends," but when it comes to lovers, it seems that finding a happy ending worthy of Ross and Rachel isn't so easy.
Jennifer Aniston became the patron saint of scorned first wives when Brad Pitt left her for Angelina Jolie. Matt LeBlanc's marriage imploded much like his "Friends" spinoff, "Joey." Matthew Perry gave up drugs only to find that he couldn't get a woman.
True, not all of them are alone (see: Lisa Kudrow, David Schwimmer), but there enough now-single "Friends" stars to start a support group at Central Perk. Below, check out how the stars of NBC's iconic sitcom have fared in the relationship department:
Tuesday on Howard Stern's Sirius radio show, Arquette revealed why the couple decided to separate after 11 years of marriage.
"We're not having sex, and I completely understand," said Arquette, 39. "She's in a place of wanting to be real and emotional. She's an emotional being. She's an amazing woman. If it doesn't feel right, she doesn't feel like bonding in that way."
Arquetted said that Cox, 46, wants him to grow up.
"She says that to me: 'I don't want to be your mother anymore,'" he said. "I appreciated that. I respected that. I've been going to therapy. I'm trying to grow up."
Cox, the star of "Cougar Town" could now be a cougar on the prowl. Rumors are swirling that Cox has been having a more-than-professional relationship with her co-star on the ABC comedy, Brian Van Holt, 40. RadarOnline.com quoted an unnamed source saying that Holt and Cox often spend time together off-set.
Aniston's made a slew of movies since "Friends," from box office hits ("Marley & Me," "The Break-Up") to romantic comedy misses ("He's Just Not That into You," "Rumor Has It"). But it seems that her love life regularly eclipses her film endeavors.
Years after her fairytale marriage with Pitt ended, she continues to talk about her feelings towards him and Jolie. In a 2008 interview with GQ magazine, Aniston characterized her relationship with the couple as "an insane Bermuda Triangle." She threw a sarcastic jab at the family of eight: "The funny thing is, people don't realize we all go away to the Hamptons on weekends ... That'd be hysterical: I've got Zahara on my hip, and Knox."
The gossip continued during an interview with Vogue. While Aniston insisted she's been "unbelievably lucky in love," she called Jolie "inappropriate" and "uncool" for talking about falling in love with Pitt while he was still married.
If the tabloids are to be believed, Aniston, 41, has had eyes for pretty much every male she's worked with since her divorce from Pitt, including her "Bounty Hunter" co-star Gerard Butler and here "Marley & Me" co-star Owen Wilson. In reality, she's had three relationships of note post-Pitt: with actor Vince Vaughn, model Paul Sculfor, and singer John Mayer.
Aniston recently teamed up with Cox for the season premiere of "Cougar Town." Now that they're both single, maybe they'll be spending time together off-set too.