They had no problem making "Friends," but when it comes to lovers, it seems that finding a happy ending worthy of Ross and Rachel isn't so easy.
Jennifer Aniston became the patron saint of scorned first wives when Brad Pitt left her for Angelina Jolie. Matt LeBlanc's marriage imploded much like his "Friends" spinoff, "Joey." Matthew Perry gave up drugs only to find that he couldn't get a woman.
True, not all of them are alone (see: Lisa Kudrow, David Schwimmer), but there enough now-single "Friends" stars to start a support group at Central Perk. Below, check out how the stars of NBC's iconic sitcom have fared in the relationship department:
Tuesday on Howard Stern's Sirius radio show, Arquette revealed why the couple decided to separate after 11 years of marriage.
"We're not having sex, and I completely understand," said Arquette, 39. "She's in a place of wanting to be real and emotional. She's an emotional being. She's an amazing woman. If it doesn't feel right, she doesn't feel like bonding in that way."
Arquetted said that Cox, 46, wants him to grow up.
"She says that to me: 'I don't want to be your mother anymore,'" he said. "I appreciated that. I respected that. I've been going to therapy. I'm trying to grow up."
Cox, the star of "Cougar Town" could now be a cougar on the prowl. Rumors are swirling that Cox has been having a more-than-professional relationship with her co-star on the ABC comedy, Brian Van Holt, 40. RadarOnline.com quoted an unnamed source saying that Holt and Cox often spend time together off-set.
Aniston's made a slew of movies since "Friends," from box office hits ("Marley & Me," "The Break-Up") to romantic comedy misses ("He's Just Not That into You," "Rumor Has It"). But it seems that her love life regularly eclipses her film endeavors.
Years after her fairytale marriage with Pitt ended, she continues to talk about her feelings towards him and Jolie. In a 2008 interview with GQ magazine, Aniston characterized her relationship with the couple as "an insane Bermuda Triangle." She threw a sarcastic jab at the family of eight: "The funny thing is, people don't realize we all go away to the Hamptons on weekends ... That'd be hysterical: I've got Zahara on my hip, and Knox."
The gossip continued during an interview with Vogue. While Aniston insisted she's been "unbelievably lucky in love," she called Jolie "inappropriate" and "uncool" for talking about falling in love with Pitt while he was still married.
If the tabloids are to be believed, Aniston, 41, has had eyes for pretty much every male she's worked with since her divorce from Pitt, including her "Bounty Hunter" co-star Gerard Butler and here "Marley & Me" co-star Owen Wilson. In reality, she's had three relationships of note post-Pitt: with actor Vince Vaughn, model Paul Sculfor, and singer John Mayer.
Aniston recently teamed up with Cox for the season premiere of "Cougar Town." Now that they're both single, maybe they'll be spending time together off-set too.
In 2006, after his ill-fated "Friends" spin-off "Joey" was cancelled, LeBlanc had few callers -- both of the professional and the personal kind.
His marriage to British model Melissa McKnight failed around the time "Joey" did. According to People magazine, the couple had trouble with their daughter, Marina, who suffered seizures from shortly after birth until she was two years old. As the couple's third anniversary approached, LeBlanc suddenly moved out and began seeing his "Joey" co-star Andrea Anders. LeBlanc, 43, also got some not-so-helpful tabloid inches after he admitted to groping a stripper at a Canadian nightclub.
Perry, 41, has struggled to find his groove since playing Chandler on "Friends." His attempts to repeat his sitcom success on the small screen have mostly fallen flat. Perry's 2006 series, "Studio 60 on the Sunset Strip," was dropped by NBC after the first season because of poor ratings. Last year, he tried again to return to television as a radio talk show host in "The End of Steve," but the dark comedy was scrapped after one episode. His latest hope: playing a selfish jerk in the upcoming ABC series "Mr. Sunshine," due to debut in 2011.
Perry hasn't had better luck on the big screen. In his first film role after "Friends," Perry played a chronically depressed man in the 2007 movie "Numb." The film flopped at the box office. His most recent role in "17 Again" was better received, but he played second string to the flim's star, Zac Efron.
In the past, Perry has admitted to struggles with depression, alcohol and prescription drug addiction. Production on 2002's "Serving Sara" had to be shut down for three months while Perry checked into rehab.
"Your consciousness has to change and, I was very lucky and smart enough to realize that at that moment, it was life and death time, and movies, acting, dating, sports and everything just have to take a sideline to this," he told Film Monthly at the time.
Through it all, he's remained chronically single (save for a two-year-long relationship with former fashion student Rachel Dunn), and he doesn't know why.
"People sometimes ask me how I've managed to get to the age of 39 and never been married. The answer is, I don't know," Britain's Daily Mail quoted Perry as saying in 2009. "I'm hoping that will change. I'm a pretty happy guy, who is looking for someone who enjoys having a good time. I'm hoping it will all work out for me in the end."
Kudrow's managed a feat none of the other "Friends" women seem to have: finding success both on set and at home.
Since hanging up Phoebe Buffay's tie-died ensembles, Kudrow, 47, has attached her name to a variety of successful movies, including "Analyze This" and its sequel, "P.S. I Love You," and "Easy A." She's currently starring in the online series "Web Therapy." And like Aniston, she made an appearance on Cox's "Cougar Town."
In 1995, Kudrow became the first of the "Friends" cast to marry, and her relationship with her husband, French advertising executive Michel Stern, still seems solid. The two have a 12-year-old son, Julian Murray.
While David Schwimmer's post-"Friends" career has had its ups and downs -- his most prominent roles have been behind the camera as a director, and he's made appearances on "Entourage" and "30 Rock" -- he's fared well on the romantic front.
In June, Schwimmer wed his British girlfriend, Zoe Buckman, at a small, private ceremony. The two reportedly met in London in 2007, while Schwimmer, 43, was directing the romantic comedy "Run, Fat Boy, Run." He crossed paths with Buckman, 25, at the Cuckoo Club in London's West End, where she worked as a waitress. Soon after they met, she moved to Los Angeles to live with him.
Despite their seemingly breezy relationship, Schwimmer may have been mindful of the "Friends" curse -- though the couple wed in June, Schwimmer didn't reveal he'd tied the knot until this month.
ABC News' Luchina Fisher contributed reporting.