Nailed: Celebs Look to Beauty's Bestseller for Latest Lines

"We really took nail polish just from being 'red #17' to something aspirational from the consumer," she said. "I mean, we took her to places that we could not imagine her to travel. Twice a year, we take her, give it fun names and she can identify with the colors as it becomes part of her life."

In fact, the number-one-selling polish for OPI is a bright shade of red called "I'm Not Really a Waitress."

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ABC News explored the massive storeroom at... View Full Caption

ABC News explored the massive storeroom at nail polish manufacturing giant OPI?s headquarters in Hollywood, Calif. Nail polish is seen in this undated image supplied by ABC News. Close

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"That was from our Hollywood collection," Weiss-Fischmann said. "You know, in Hollywood, everybody's an actor and actress and many of them, unfortunately, have to be waitresses in order to pay the bills...it's an incredible seller we launched 10 years ago and it's still number one."

"You Don't Know Jacques," (a neutral gray), "Bubble Bath," (a light pink), "Link'n Park After Dark," (a dark purple) and "Big Apple Red" (a bright red) round out the top-five selling names for OPI.

The "shattered" look featured in both Serena Williams and Katy Petty's polish lines from OPI are the next revolution found on painted fingers. As the paint dries, it appears to crack and leaves smooth, dramatic fissures of color on the nail.

"This is a product that you can individualize art," said OPI manicurist Eleanor Victor.

ABC News' Lauren Effron contributed to this report