Excerpts from Moore's follow-up to "Fahrenheit 9/11" -- "Sicko," a documentary on the health-care system -- will be unveiled, along with another film-in-progress, "The Great '04 Slacker Uprising," about his rabble-rousing travels during the 2004 presidential election.
A British film that depicts the fictionalized assassination of President Bush -- "D.O.A.P." or "Death of a President" -- makes its North American debut.
Festival goers will also see the Dixie Chicks documentary, "Shut Up and Sing," about the furor after singer Natalie Maines told a British concert audience in 2003, "We're ashamed the president of the United States is from Texas."
Here's a rundown of some of the most talked-about films, of the 352 that will be shown:
"All the King's Men" -- Sean Penn stars as a corrupt Louisiana politician in a new adaptation of Robert Penn Warren's novel. This is a remake of the 1949 film that won best picture.
"A Good Year" -- Crowe can do a sword-and-sandals epic, but can he do romantic comedy, as a financier looking for love? He'll be tutored by co-star Albert Finney, who plays his womanizing uncle.
"Volver" -- Acclaimed Spanish director Pedro Almodovar reunites with leading lady Penelope Cruz in a tale about an abused woman.
"Babel" -- One of the top films at Cannes, a political thriller starring Pitt.
"Stranger Than Fiction" -- The big question here: Can Will Ferrell act? He's tried his hand in a Woody Allen film, but he'll test his thespian skills as an IRS agent alongside Emma Thompson, who plays a neurotic writer.
"Infamous" -- Featuring Daniel Craig, the next James Bond, this time playing killer Perry Smith, in a film about Truman Capote's research into the true-crime novel that became "In Cold Blood." Toby Jones will play the controversial writer (and not Philip Seymour Hoffman, who won an Oscar for "Capote"), with Sandra Bullock as Harper Lee.
"El Cantante" -- A biopic about 1960s Puerto Rican salsa king Hector Lavoe and his struggles with addiction and loss, starring Marc Anthony and Lopez.
"Penelope" -- Witherspoon stars and serves as producer in this tale of a woman (Christina Ricci), who tries to shake off a family curse.
"For Your Consideration" -- Christopher Guest, the director of such comic classics as "Best in Show" and "A Mighty Wind," has rounded up much of the same ensemble -- including Catherine O'Hara, Eugene Levy, Parker Posey, Harry Shearer and Michael McKean -- for another romp. This one turns to actors caught up in the frenzy after their independent movie catches awards buzz.