♪ John travolta, kirstie al alley, their names spell dynamite in the "look who's talking" movie. Bianna golodryga has more. ♪ Very pretty ♪ Reporter: They first fell in... See More
♪ John travolta, kirstie al alley, their names spell dynamite in the "look who's talking" movie. Bianna golodryga has more. ♪ Very pretty ♪ Reporter: They first fell in love on screen in "look who's talking." In real life, they've been best friends ever since. Now kirstie alley and john travolta are rekindling that on-screen flame reuniting on alley's tv land sitcom "kirstie." I just wanted to introduce myself. I'm mickey russo. Would you like plea to sign your program or something more intimate? Reporter: On the show alley plays a broadway star and in his guest spot tonight, travolta is a stagehand. What a reunion. How did this come about? He called me and begged me to be on the show. I said, john, hold up. He goes, please. Please. I went. This day has been so exciting. I loved every second of it. I counted every second of it. Reporter: Mickey is a little dense. The mani/pedi. That's what you call it short for manicure/pedicure. Wow. It's supposed to be a one-night stand although he's the idiot of the universe he's good in bed. We've all had those. Good morning. Reporter: What is it about the chemistry that the two of you have that work so well on camera? I don't know. I think we like each other. I think we like each other. Reporter: How long have you known each other? 67 years. Reporter: We've seen them fall in and out of love, marry, have kids, dogs and always so much fun. You know, that's breast milk. I'm the one who got you fired. What? Why? To be mean. I'm really mean. No. No. Reporter: Do you think that's what built the great chemistry the two of you had? Kirstie was a person I could have fun with and play with. Whoa, baby. Hot mama. Goofball. We just can't help but go to playing. Reporter: Good-bye. We can't see each other anymore. This is good-bye. Reporter: But not for long. Hug. Reporter: For "good morning america," bianna golodryga, abc news, los angeles. Thank you, bianna. That episode of "kirstie" with john travolta airing on tv land tonight.
This transcript has been automatically generated and may not be 100% accurate.