Christina Applegate's Pregnancy After Cancer Treatment Isn't Risky

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After beating breast cancer, actress Christina Applegate will soon move on to perhaps her most challenging role yet: motherhood.

The former sitcom star, 38, has announced that she is expecting her first child, coming two years after she underwent a double mastectomy in July 2008.

She told "Good Morning America" a month after the surgery that she was "100 percent" cancer-free.

While Applegate may be one of the most high-profile women to get pregnant after undergoing breast-cancer treatment, she certainly isn't alone.

VIDEO: Is it safe to have a baby after beating breast cancer?
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Susan Cacioppo of Port Washington, N.Y., found herself in a similar situation several years ago.

Susan was diagnosed with a serious form of breast cancer in 1996 when she was 32.

"I had 25 positive lymph nodes with cancer," Cacioppo said.

After surgery and several months of chemotherapy, her doctor told her that if she could still have a child after the chemotherapy she had, she would have to wait five years before getting pregnant.

"I went for scans every year," she said. "They were always looking for cancer and, fortunately, I was always good."

The five-year mark came and she decided she was ready to try for a second child.

"It was always in the back of my mind that I wanted to have a baby," she said. "My son wanted a brother or sister."

After discussing it with her doctor, she went for more tests to check for any signs of cancer. There were none. In 2001, she had a healthy baby boy.

During the five years between the end of her chemotherapy and her pregnancy, she often worried about whether she would ever have another child, and also whether she would live to see that day.

"I was always praying that I would be healthy and hoping that I would make it to the next checkup," she said.

She also worried about whether being pregnant would put her at risk for a recurrence of her cancer, or for the development of other cancers.

"Everybody worries about that," she said.

Breast Cancer Survivorship No Barrier to Pregnancy

But medical experts say that while it's something women do worry about, studies have shown that pregnancy a certain period of time after breast cancer treatment is no more dangerous than becoming pregnant at any other time.

"Becoming pregnant immediately after treatment may be associated with an increased risk of recurrence," said Dr. Massimo Cristofanilli, chair of the department of medical oncology at Fox Chase Cancer Center in Philadelphia.

Indeed, research has shown that pregnancy may actually protect women against a recurrence of cancer.

"Studies showed an improvement in outcomes in women who eventually became pregnant after two to five years," he said. "It's possibly a protective effect, there are fewer ovulatory cycles, so there's less estrogen," he added.

Appropriate Time Frame May Vary

Recommendations for when it's safe for women to get pregnant vary on a case-by-case basis and often depend on age and stage of cancer, but doctors generally adhere to a standard protocol.

"For those women who have already had surgery and chemotherapy and took care of their cancer, doctors usually recommend not getting pregnant until they've been cancer-free for two years," said Dr. Daniel Roshan, assistant professor of obstetrics and gynecology at NYU School of Medicine.

Roshan also recommended that women do the following, depending on their situation:

Older women who may not want to wait two years can freeze their embryos or get donor eggs later.

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