Man Doses Himself With a Parasite for Intestinal Problems

VIDEO: Boston Med
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Catching an intestinal parasite is not usually considered desirable, but for a California man with severe gastrointestinal problems, dosing himself with worms was the answer to his prayers.

After reading preliminary research that suggested a whipworm found in pigs could help those with ulcerative colitis, the 34-year-old patient tracked down and ingested eggs from Trichuris trichiura, a similar roundworm that infects humans, in hopes of easing his own colitis.

After a few months, the abdominal pain and bloody diarrhea associated with the patient's ulcerative colitis improved dramatically, and after a second "booster" dose of worm eggs, he remains in remission more than four years later.

In hopes of better understanding how certain parasitic worms can be used to heal, doctors at New York University Langone Medical Center ran extensive testing on this man, the results of which were published Wednesday in Science Translational Medicine.

"Essentially this patient has been in remission for several years, with no other medication. For this individual, the goal is to remain infected for the rest of his life, but it's hard to know if that's a viable strategy for everyone. We don't have a good understanding of the risk," said P'ng Loke, assistant professor of medical parasitology at NYU Langone Medical Center and lead author of the study.

Treating colitis with worms is not new. The first human trials using pig whipworm took place in 2005. and this worm is being developed as a possible colitis vaccine, said Dr. Joel Weinstock, who pioneered this research while at the University of Iowa Carver College of Medicine. But Loke's case study may shed more light on how these worms protect and heal the colon.

Researchers found that the parasite works by inciting a specific type of immune response. In an attempt to rid the body of the worms, the immune system signals the body to produce more mucus, which in turn protects the lining of the gut from the ulcers and inflammation caused by the colitis.

Wonder Worms

Colitis isn't the only condition these little worms could possibly treat. In the past five years, research has suggested that other autoimmune disorders, such as Crohn's disease, an inflammatory bowel disease, and multiple sclerosis, which affects the brain and spinal cord, may also benefit from a targeted parasitic infection.

For Crohn's, MS and colitis, an overactive immune response results in excessive inflammation in the body. There are multiple ways that the immune system can fight off perceived threats, but with these disorders, the body sends out a nonspecific inflammation response that can ultimately harm the body's tissues. This blanket immune response is known as the Th1 pattern.

Becoming infected with whipworms, however, incites a very different immune response, known as Th2, said Dr. Gerard Mullin, director of Integrative Nutrition Services at the Johns Hopkins Hospital. "It's like a yin yang. The Th2 response is anti-inflammatory in nature, and it counteracts the Th1 response," he said.

Loke's study also suggests that the specific immune cells that are stimulated by the body's reaction to whipworms are particularly helpful because they regulate the amount of mucus in the gut.

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