Using a the combination of medications may also be inconvenient, he said, because it involves taking multiple pills.
Other over-the-counter options include other medicines such as ibuprofen or naproxen, but they also don't work for everyone.
"Migraine is a spectrum. Some people have mild to moderate headaches, and others have moderate to severe, and over-the-counter medicines help a percentage of migraine patients who have mild headaches."
While Excedrin certainly works for many people, Saper warned against its overuse.
"You have to be careful with these drugs. You can get trapped in them. "It's not addictive by its components, but in some cases, the more you take it, the more headaches you have, then the more you take and it may start to actually drive the headaches."
For Terjesen, it's been a long wait that she hopes is over soon.
"I am very eager to try to get back on it or at least have the option," she said. "It was a game changer for me."