After more than 40 years in public office, Sen. Harry Reid, the most powerful man in the Senate, faces the prospect of losing to Tea Party activist Sharron Angle.
When asked by reporters how Angle holds up compared to his opponents in the past, the Senate majority leader could barely hide his contempt.
"Really, honestly, way at the bottom, but for the economy, there wouldn't be a contest here," said Reid, who represents a state that leads the country in unemployment and foreclosures.
Tea Party candidates across the country are looking at mixed prospects. Republican Senate candidate Ken Buck of Colorado is leading in the polls in the purple state, as is Marco Rubio in Florida and Rand Paul in Kentucky.
But another conservative who rode to victory in primaries on the back of Tea Party support is facing a last-minute uphill fight. Joe Miller, the Senate candidate in Alaska who beat Sen. Lisa Murkowski, is now seeing support from his Republican backers move to the incumbent.
In Delaware, candidate Christine O'Donnell -- who famously pronounced in a TV ad that she is not a witch -- is trailing well behind in the polls to Democrat Chris Coons.
Sarah Palin promised she would campaign for the fledgling candidate but the two haven't made a joint appearance. Palin campaigned with Miller last week in Alaska.
ABC News' Jake Tapper and Jonathan Karl contributed to this report.