Lorenzi has not won a Grand Slam match in 13 appearances at majors. Only Juan Antonio Marin of Costa Rica has a worse record -- zero wins in 17 Grand Slam matches.
Federer, also attempting to win his 18th Grand Slam title, lost in the second round here last year, his earliest defeat at Wimbledon since 2002. He finished Tuesday's match with his ninth ace.
It is Federer's 16th consecutive appearance at Wimbledon and his 59th Grand Slam event in a row, extending his record for the longest streak of consecutive majors in the Open era.
Wawrinka, who served 18 aces, lost in the first round at the French Open in his first Grand Slam since winning his first major at Melbourne in January.
The Swiss player had lost five times in the first round at Wimbledon, including the past two years.
The 14th-seeded Frenchman was set to serve for the match at 5-4 in the deciding set when rain forced a suspension and eventually a postponement of the first-round match Monday.
Tsonga, a two-time semifinalist at Wimbledon, came back out Tuesday and held serve at love, finishing with his 20th ace, to complete a 6-1, 3-6, 3-6, 6-2, 6-4 win.
Information from The Associated Press was used in this report.