Adele told the crowd, "I'm dedicating this show tonight to them because honestly I'm really, really sad."
"I don't like gossiping and private lives should be private, but I feel like it's the end of an era," she added. "I was shocked!"
On Monday, Jolie, 41, filed for divorce from her husband of two years, 52. She cited irreconcilable differences and has asked for physical custody of their six children.
"I am very saddened by this, but what matters most now is the well-being of our kids," Pitt told People magazine about the split.