"Can we please start it again? I'm sorry, I can't mess this up for him," she said after getting tripped up after just a few lines of Michael's 1996 song, "Fastlove."
After her second performance of the night, Adele was visibly in tears, mouthing "thanks" to a sympathetic audience.
"The 'Lemonade' album was just so monumental and so well thought out and so beautiful and soul-barring," Adele explained to the audience during her acceptance speech, "and we appreciate that."
A tribute to Prince went off without a hitch. The Purple One was honored by The Time, a Minneapolis band he helped create. Bruno Mars, wearing a Prince-inspired purple suit, later performed "Let's Go Crazy," as he showcased his impeccable guitar skills.
Although Beyonce lost in most of her nominated categories to Adele, the pregnant singer's performance lit up social media. She took the stage performing "Love Drought" and "Sandcastles" in a golden ensemble featuring a halo.
Bey did, however, take home a trophy for best urban contemporary album for "Lemonade." During her acceptance speech she told the audience "it's vital that we learn from the past and recognize our tendencies so we won't repeat our own mistakes."
A hilarious moment came when Twenty One Pilots took off their pants to accept the award for best pop duo/group performance for their song, "Stressed Out." The duo explained that previously when they were watching the Grammys at home, drummer Josh Dun noticed that they were all in their underwear.
The band said then that "if we ever win a Grammy, we should receive it just like this."
Chance the Rapper won a coveted award -- best new artist. He also used the opportunity to clarify what it meant to be an artist not connected to a record label. The Chicago rapper, who won a total of three Grammys Sunday night, put out his debut album, "Coloring Book," exclusively on Apple Music before it was released on other streaming services. "Independent doesn't mean you do it by yourself, but independence means freedom," he said.
He later performed a medley of his distinctive gospel-infused hip-hop hits.