However, his acceptance speech was what truly won over the audience.
"It's a humbling thing when you find someone to love. [It's] even better if you've been waiting your whole life," he said. "Amal, whatever alchemy it is that brought us together I couldn't be more proud to be your husband."
Clooney, whose wife wore a "Je suis Charlie" badge to the show, also discussed the tragic events that recently unfolded in Paris, and the demonstrations that took place earlier in the day in solidarity with the victims of the shooting at French satirical newspaper Charlie Hebdo.
"We will not walk in fear," he said. "We will not do it. Je suis Charlie."