It was also an outstanding night for women, who were the big winners in film and television.
"Clearly all the shows and movies that won were women-centric," said Melissa Silverstein, the founder and editor of the website Women and Hollywood. "That’s all of them."
On the TV side, "Big Little Lies," "The Handmaid's Tale" and "The Marvelous Mrs. Maisel" were the big winners, while the big screen's "Three Billboards Outside Ebbing, Missouri" and "Lady Bird" took home multiple honors.
Beyond the awards, women controlled the narrative Sunday night by showing solidarity with victims of sexual harassment and assault through their support of the new Time's Up campaign.
"I was blown away by Oprah’s speech but I knew it was going to be awesome," Silverstein said.
Winfrey's rousing speech -- which drew on life-changing childhood memories, alluded to the #MeToo movement and spoke to future generations of women -- was the most tweeted-about moment from the Globes.
But she wasn't the only one making headlines.
Natalie Portman, a founding member of the Time's Up campaign, pointed out the obvious while presenting nominees for best director.
"And here are the all male nominees," she said before reading out the list.
"I think Oprah inspired people and Natalie Portman put them on notice," Silverstein said.
Introduced as the only woman to ever receive the best director award in the history of the Globes for "Yentl," Streisand pointed out that honor came more than three decades ago.
"That was 1984, that was 34 years ago. Folks, time’s up!" she said from the stage.
"The lack of women directors was so prominent, and on an awards show it’s just amazing," Silverstein said. "This is not going to go away, this is going to continue to go on. And the way to solve the problem is to hire more women directors."
While women basked in the spotlight at the show Sunday night, men -- with a few exceptions -- seemed to take a backseat.
"Not only did they fade into the background," Silverstein said, "but they did not step up in the way they needed to be as allies. They still need a lot of work to understand how they are part of the problem."
That may have ended the show but it did not take away from the historic night.
"There's still a long way to go," Silverstein said, "but it was a great, amazing first step."