The gesture is in honor of Time's Up, which aims to spark conversation around "equality and safety in the workplace," music executive Karen Rait said ahead of the ceremony.
Stars such as Khalid, The Chainsmokers, Imagine Dragons and Lady Gaga were spotted with white roses on the carpet.
Kelly Clarkson, who held her white rose, said on "E! Live from the Red Carpet" that after looking into what the white rose represented she decided to join the movement.
"It represents hope and peace and sympathy and resistance," she said. "Those are lovely things for every human to encompass."
Cindy Lauper said she was holding a white rose because she believes "equity in the workforce will help not just women but men, too."
British singer Sam Smith, who wore on a rose on his lapel, said he was supporting the Time's Up initiative because he believes it'll have a positive impact on the gay community.
"I hope we get better and I just hope we keep striving forward for equality for absolutely everyone," he said on "E! Live." "Being a gay man, we need that as a community and the world needs it now."