Their reps confirmed to E! News in a statement that the couple has "mutually decided to end their marriage."
"Mandy Moore and Ryan Adams have mutually decided to end their marriage of almost six years," reps for the couple said. "It is a respectful, amicable parting of ways and both Mandy and Ryan are asking for media to respect their privacy at this time."
The "Tangled" actress, 30, and Adams, 40, announced their engagement in February of 2009 and married a month later. They worked together a bit, most recently, with Moore provided vocals on Adams' recent, self-titled album.
They do not have any children.