The film portrays the true story of a real-life friendship between Rogers and journalist Tom Junod, a jaded magazine writer whose heart was melted by America's favorite neighbor.
Emmy-winner Matthew Rhys plays the reporter, who eventually understands the empathy and kindness Rogers taught millions by example.
"You like broken people like me," Junod says, to which Hanks' Rogers replies, "Sometimes we have to ask for help. And that's OK."
Affecting Rogers' famously soft-spoken voice, the two-time Oscar winner says, "I think the best thing we can do is let people know that each one of them is precious."
The movie comes out this Thanksgiving.